Interações medicamentosas
Cefoxitin + Chloramphenicol
Gravidade: Moderada
Cefoxitin and Chloramphenicol: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Chloramphenicol is bacteriostatic and may reduce the bactericidal activity of beta-lactams such as cefoxitin in laboratory models. Clinical evidence of treatment failure is limited and mostly from older data in meningitis and severe infections. The concern is mainly for serious infections where rapid killing matters.
O que esta interação significa em palavras simples
Cefoxitin and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefoxitin belongs to Anti Bacterial; Chloramphenicol belongs to Anti Bacterial.
Por que acontece
Pharmacodynamic antagonism: inhibition of bacterial protein synthesis by chloramphenicol may blunt the growth-dependent killing by beta-lactams.
O que fazer
Avoid combining them for serious infections where bactericidal activity is needed; if both are required, monitor clinical response closely.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefoxitin
- Amikacin + Cefoxitin Moderada
- Aztreonam + Cefoxitin Moderada
- Bcg vaccine live + Cefoxitin Moderada
- Cefoxitin + Cholera vaccine Moderada
- Cefoxitin + Dexamethasone-tobramycin Moderada
- Cefoxitin + Gentamicin Moderada
Outras interações de Chloramphenicol
Perguntas frequentes
Can I take Cefoxitin with Chloramphenicol?
MediHelp rates the interaction as moderate. Cefoxitin and Chloramphenicol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chloramphenicol is bacteriostatic and may reduce the bactericidal activity of beta-lactams such as cefoxitin in laboratory models. Clinical evidence of treatment failure is limited and mostly from older data in meningitis and severe infections. The concern is mainly for serious infections where rapid killing matters.
How serious is the interaction between Cefoxitin and Chloramphenicol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining them for serious infections where bactericidal activity is needed; if both are required, monitor clinical response closely.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.
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