Interações medicamentosas
Cefoxitin + Kanamycin
Gravidade: Moderada
Cefoxitin and Kanamycin: moderate interaction.
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Resumo
Giving a cephalosporin with an aminoglycoside may add to kidney injury, and aminoglycosides can also damage the inner ear. The risk is greatest in patients with existing renal impairment, older adults or those receiving prolonged courses.
O que esta interação significa em palavras simples
Cefoxitin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Additive nephrotoxic potential, with aminoglycoside-related tubular injury and ototoxicity possibly aggravated by reduced renal clearance.
O que fazer
Monitor serum creatinine and urine output during combined therapy and check kanamycin levels where available. Adjust the aminoglycoside dose to renal function and report any hearing or balance symptoms promptly.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefoxitin
- Amikacin + Cefoxitin Moderada
- Aztreonam + Cefoxitin Moderada
- Bcg vaccine live + Cefoxitin Moderada
- Cefoxitin + Chloramphenicol Moderada
- Cefoxitin + Cholera vaccine Moderada
- Cefoxitin + Dexamethasone-tobramycin Moderada
Perguntas frequentes
Can I take Cefoxitin with Kanamycin?
MediHelp rates the interaction as moderate. Cefoxitin and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Giving a cephalosporin with an aminoglycoside may add to kidney injury, and aminoglycosides can also damage the inner ear. The risk is greatest in patients with existing renal impairment, older adults or those receiving prolonged courses.
How serious is the interaction between Cefoxitin and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output during combined therapy and check kanamycin levels where available. Adjust the aminoglycoside dose to renal function and report any hearing or balance symptoms promptly.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.
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