Interações medicamentosas
Cefpodoxime + Gentamicin
Gravidade: Moderada
Cefpodoxime and Gentamicin: moderate interaction.
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Resumo
Cephalosporins have been reported to add to aminoglycoside nephrotoxicity, though oral cefpodoxime has low direct renal toxicity. Risk is higher in patients with kidney impairment, older age, or dehydration.
O que esta interação significa em palavras simples
Cefpodoxime and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefpodoxime belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
Por que acontece
Possible additive renal tubular injury; cefpodoxime itself is rarely nephrotoxic.
O que fazer
Monitor serum creatinine and gentamicin levels during co-therapy, and adjust gentamicin dosing to renal function. Maintain hydration.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefpodoxime
- Aluminum hydroxide + Cefpodoxime Moderada
- Amikacin + Cefpodoxime Moderada
- Calcium carbonate + Cefpodoxime Moderada
- Calcium + Cefpodoxime Moderada
- Cefpodoxime + Cholera vaccine Moderada
- Cefpodoxime + Cimetidine Moderada
Outras interações de Gentamicin
Perguntas frequentes
Can I take Cefpodoxime with Gentamicin?
MediHelp rates the interaction as moderate. Cefpodoxime and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cephalosporins have been reported to add to aminoglycoside nephrotoxicity, though oral cefpodoxime has low direct renal toxicity. Risk is higher in patients with kidney impairment, older age, or dehydration.
How serious is the interaction between Cefpodoxime and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin levels during co-therapy, and adjust gentamicin dosing to renal function. Maintain hydration.
What other medicines interact with Cefpodoxime?
MediHelp also lists interactions of Cefpodoxime with, for example, Aluminum hydroxide, Amikacin, Calcium carbonate. The full list is on the Cefpodoxime page.
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