Interações medicamentosas
Ceftazidime + Kanamycin
Gravidade: Moderada
Ceftazidime and Kanamycin: moderate interaction.
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Resumo
Ceftazidime given with an aminoglycoside such as kanamycin may add to kidney injury risk, and aminoglycosides also carry ototoxic potential. The risk is greatest in patients with pre-existing renal impairment, older age, dehydration or prolonged therapy. Combination is used clinically but warrants monitoring.
O que esta interação significa em palavras simples
Ceftazidime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Additive nephrotoxicity, with aminoglycoside-related ototoxicity and renal accumulation possibly aggravated by reduced renal function.
O que fazer
Monitor serum creatinine and urine output regularly, and adjust ceftazidime and kanamycin doses to renal function. Check aminoglycoside levels where available and monitor hearing and vestibular symptoms.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Ceftazidime
- Amikacin + Ceftazidime Moderada
- Ceftazidime + Cholera vaccine Moderada
- Ceftazidime + Dexamethasone-tobramycin Moderada
- Ceftazidime + Gentamicin Moderada
- Ceftazidime + Microbiota Moderada
- Ceftazidime + Plazomicin Moderada
Perguntas frequentes
Can I take Ceftazidime with Kanamycin?
MediHelp rates the interaction as moderate. Ceftazidime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceftazidime given with an aminoglycoside such as kanamycin may add to kidney injury risk, and aminoglycosides also carry ototoxic potential. The risk is greatest in patients with pre-existing renal impairment, older age, dehydration or prolonged therapy. Combination is used clinically but warrants monitoring.
How serious is the interaction between Ceftazidime and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output regularly, and adjust ceftazidime and kanamycin doses to renal function. Check aminoglycoside levels where available and monitor hearing and vestibular symptoms.
What other medicines interact with Ceftazidime?
MediHelp also lists interactions of Ceftazidime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Ceftazidime page.
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