Drug interactions
Ceftazidime + Kanamycin
Severity: Moderate
Ceftazidime and Kanamycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftazidime given with an aminoglycoside such as kanamycin may add to kidney injury risk, and aminoglycosides also carry ototoxic potential. The risk is greatest in patients with pre-existing renal impairment, older age, dehydration or prolonged therapy. Combination is used clinically but warrants monitoring.
What this interaction means in plain words
Ceftazidime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive nephrotoxicity, with aminoglycoside-related ototoxicity and renal accumulation possibly aggravated by reduced renal function.
What to do
Monitor serum creatinine and urine output regularly, and adjust ceftazidime and kanamycin doses to renal function. Check aminoglycoside levels where available and monitor hearing and vestibular symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ceftazidime
- Amikacin + Ceftazidime Moderate
- Ceftazidime + Cholera vaccine Moderate
- Ceftazidime + Dexamethasone-tobramycin Moderate
- Ceftazidime + Gentamicin Moderate
- Ceftazidime + Microbiota Moderate
- Ceftazidime + Plazomicin Moderate
Frequently asked questions
Can I take Ceftazidime with Kanamycin?
MediHelp rates the interaction as moderate. Ceftazidime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceftazidime given with an aminoglycoside such as kanamycin may add to kidney injury risk, and aminoglycosides also carry ototoxic potential. The risk is greatest in patients with pre-existing renal impairment, older age, dehydration or prolonged therapy. Combination is used clinically but warrants monitoring.
How serious is the interaction between Ceftazidime and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output regularly, and adjust ceftazidime and kanamycin doses to renal function. Check aminoglycoside levels where available and monitor hearing and vestibular symptoms.
What other medicines interact with Ceftazidime?
MediHelp also lists interactions of Ceftazidime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Ceftazidime page.
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