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Interações medicamentosas

Ceftazidime + Plazomicin

Gravidade: Moderada

Ceftazidime and Plazomicin: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Plazomicin is nephrotoxic, ototoxic and can cause neuromuscular blockade, and concurrent use with ceftazidime may add to renal stress. The combination is sometimes used deliberately for resistant Gram-negative infection, but kidney function can deteriorate.

O que esta interação significa em palavras simples

Ceftazidime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Ceftazidime belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.

Nível de evidência: Low

Por que acontece

Additive nephrotoxic potential, with impaired renal function raising plazomicin exposure and ototoxic risk.

O que fazer

Monitor serum creatinine frequently and use plazomicin therapeutic drug monitoring if available. Adjust doses to renal function and watch for hearing or balance changes.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Ceftazidime with Plazomicin?

MediHelp rates the interaction as moderate. Ceftazidime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Plazomicin is nephrotoxic, ototoxic and can cause neuromuscular blockade, and concurrent use with ceftazidime may add to renal stress. The combination is sometimes used deliberately for resistant Gram-negative infection, but kidney function can deteriorate.

How serious is the interaction between Ceftazidime and Plazomicin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine frequently and use plazomicin therapeutic drug monitoring if available. Adjust doses to renal function and watch for hearing or balance changes.

What other medicines interact with Ceftazidime?

MediHelp also lists interactions of Ceftazidime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Ceftazidime page.

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