Interações medicamentosas
Ceftazidime + Tobramycin
Gravidade: Moderada
Ceftazidime and Tobramycin: moderate interaction.
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Resumo
Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and tobramycin itself can damage the kidneys and inner ear. The additive risk with ceftazidime is modest and mainly relevant in patients with renal impairment, older age or dehydration.
O que esta interação significa em palavras simples
Ceftazidime and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceftazidime belongs to Anti Bacterial; Tobramycin belongs to Anti Bacterial.
Por que acontece
Possible additive nephrotoxicity, with reduced renal function leading to higher aminoglycoside exposure and greater ototoxic potential.
O que fazer
Monitor serum creatinine and tobramycin trough levels, and adjust the dose to renal function. Keep the patient hydrated and assess hearing and balance if therapy is prolonged.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Ceftazidime
- Amikacin + Ceftazidime Moderada
- Ceftazidime + Cholera vaccine Moderada
- Ceftazidime + Dexamethasone-tobramycin Moderada
- Ceftazidime + Gentamicin Moderada
- Ceftazidime + Kanamycin Moderada
- Ceftazidime + Microbiota Moderada
Outras interações de Tobramycin
- Cidofovir + Tobramycin Contraindicada
- Adefovir + Tobramycin Grave
- Amikacin + Tobramycin Grave
- Amphotericin b deoxycholate + Tobramycin Grave
- Amphotericin b + Tobramycin Grave
- Atracurium + Tobramycin Grave
Perguntas frequentes
Can I take Ceftazidime with Tobramycin?
MediHelp rates the interaction as moderate. Ceftazidime and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and tobramycin itself can damage the kidneys and inner ear. The additive risk with ceftazidime is modest and mainly relevant in patients with renal impairment, older age or dehydration.
How serious is the interaction between Ceftazidime and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin trough levels, and adjust the dose to renal function. Keep the patient hydrated and assess hearing and balance if therapy is prolonged.
What other medicines interact with Ceftazidime?
MediHelp also lists interactions of Ceftazidime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Ceftazidime page.
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