Interações medicamentosas
Chloramphenicol + Lemborexant
Gravidade: Grave
Chloramphenicol and Lemborexant: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Lemborexant is metabolized mainly by CYP3A4, and inhibitors increase its exposure. This may cause excessive somnolence, next-day impairment and complex sleep behaviors.
O que esta interação significa em palavras simples
Chloramphenicol and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Lemborexant belongs to Central Nervous System.
Por que acontece
Chloramphenicol inhibits CYP3A4, reducing lemborexant clearance.
O que fazer
Avoid the combination and consider another hypnotic or antibiotic. If lemborexant must continue, use the lowest dose and monitor for daytime sedation.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Chloramphenicol e Lemborexant, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Chloramphenicol
Outras interações de Lemborexant
Perguntas frequentes
Can I take Chloramphenicol with Lemborexant?
MediHelp rates the interaction as major. Chloramphenicol and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lemborexant is metabolized mainly by CYP3A4, and inhibitors increase its exposure. This may cause excessive somnolence, next-day impairment and complex sleep behaviors.
How serious is the interaction between Chloramphenicol and Lemborexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider another hypnotic or antibiotic. If lemborexant must continue, use the lowest dose and monitor for daytime sedation.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
