Interações medicamentosas
Chloramphenicol + Selumetinib
Gravidade: Grave
Chloramphenicol and Selumetinib: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Selumetinib is metabolized mainly by CYP3A4, so chloramphenicol may increase its exposure. This may worsen adverse effects such as GI toxicity, rash, cardiomyopathy and ocular toxicity.
O que esta interação significa em palavras simples
Chloramphenicol and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chloramphenicol belongs to Anti Bacterial; Selumetinib belongs to Oncology.
Por que acontece
Chloramphenicol inhibits CYP3A4 metabolism of selumetinib.
O que fazer
Use an alternative antibiotic. If unavoidable, reduce the selumetinib dose per labeling and monitor for toxicity.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chloramphenicol
Outras interações de Selumetinib
Perguntas frequentes
Can I take Chloramphenicol with Selumetinib?
MediHelp rates the interaction as major. Chloramphenicol and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selumetinib is metabolized mainly by CYP3A4, so chloramphenicol may increase its exposure. This may worsen adverse effects such as GI toxicity, rash, cardiomyopathy and ocular toxicity.
How serious is the interaction between Chloramphenicol and Selumetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antibiotic. If unavoidable, reduce the selumetinib dose per labeling and monitor for toxicity.
What other medicines interact with Chloramphenicol?
MediHelp also lists interactions of Chloramphenicol with, for example, Adagrasib, Avapritinib, Bcg vaccine live. The full list is on the Chloramphenicol page.
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