Interações medicamentosas
Cyclosporin + Selumetinib
Gravidade: Grave
Cyclosporin and Selumetinib: major interaction.
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Resumo
Cyclosporine is a CYP3A4 inhibitor and can increase selumetinib concentrations. This raises the risk of selumetinib toxicities such as gastrointestinal effects, rash, and cardiomyopathy.
O que esta interação significa em palavras simples
Cyclosporin and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Selumetinib belongs to Oncology.
Por que acontece
Inhibition of CYP3A4-mediated metabolism of selumetinib.
O que fazer
Avoid if possible; otherwise reduce the selumetinib dose per its labeling and monitor for adverse effects. Restore the original dose about three half-lives after stopping the inhibitor.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicada
- Aliskiren + Cyclosporin Contraindicada
- Bcg vaccine live + Cyclosporin Contraindicada
- Bosentan + Cyclosporin Contraindicada
- Cidofovir + Cyclosporin Contraindicada
- Cyclosporin + Dengue vaccine Contraindicada
Outras interações de Selumetinib
Perguntas frequentes
Can I take Cyclosporin with Selumetinib?
MediHelp rates the interaction as major. Cyclosporin and Selumetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine is a CYP3A4 inhibitor and can increase selumetinib concentrations. This raises the risk of selumetinib toxicities such as gastrointestinal effects, rash, and cardiomyopathy.
How serious is the interaction between Cyclosporin and Selumetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise reduce the selumetinib dose per its labeling and monitor for adverse effects. Restore the original dose about three half-lives after stopping the inhibitor.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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