Interações medicamentosas
Chlorothiazide + Ergocalciferol
Gravidade: Moderada
Chlorothiazide and Ergocalciferol: moderate interaction.
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Resumo
Thiazide diuretics reduce urinary calcium excretion, and vitamin D increases calcium absorption from the gut. Combined use can lead to hypercalcemia, especially with high vitamin D doses or underlying hyperparathyroidism or renal disease.
O que esta interação significa em palavras simples
Chlorothiazide and Ergocalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Ergocalciferol belongs to Musculoskeletal.
Por que acontece
Thiazides increase renal tubular calcium reabsorption, adding to vitamin D-mediated increases in calcium absorption.
O que fazer
Monitor serum calcium at baseline and periodically during therapy. Reduce the vitamin D dose or reconsider the thiazide if hypercalcemia occurs.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Ergocalciferol
- Aluminum hydroxide + Ergocalciferol Moderada
- Calcium acetate + Ergocalciferol Moderada
- Calcium carbonate + Ergocalciferol Moderada
- Calcium chloride + Ergocalciferol Moderada
- Calcium citrate + Ergocalciferol Moderada
- Calcium gluconate + Ergocalciferol Moderada
Outras interações de Chlorothiazide
Perguntas frequentes
Can I take Chlorothiazide with Ergocalciferol?
MediHelp rates the interaction as moderate. Chlorothiazide and Ergocalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, and vitamin D increases calcium absorption from the gut. Combined use can lead to hypercalcemia, especially with high vitamin D doses or underlying hyperparathyroidism or renal disease.
How serious is the interaction between Chlorothiazide and Ergocalciferol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium at baseline and periodically during therapy. Reduce the vitamin D dose or reconsider the thiazide if hypercalcemia occurs.
What other medicines interact with Ergocalciferol?
MediHelp also lists interactions of Ergocalciferol with, for example, Aluminum hydroxide, Calcium acetate, Calcium carbonate. The full list is on the Ergocalciferol page.
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