Drug interactions
Chlorothiazide + Ergocalciferol
Severity: Moderate
Chlorothiazide and Ergocalciferol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics reduce urinary calcium excretion, and vitamin D increases calcium absorption from the gut. Combined use can lead to hypercalcemia, especially with high vitamin D doses or underlying hyperparathyroidism or renal disease.
What this interaction means in plain words
Chlorothiazide and Ergocalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chlorothiazide belongs to Cardiovascular; Ergocalciferol belongs to Musculoskeletal.
Why it happens
Thiazides increase renal tubular calcium reabsorption, adding to vitamin D-mediated increases in calcium absorption.
What to do
Monitor serum calcium at baseline and periodically during therapy. Reduce the vitamin D dose or reconsider the thiazide if hypercalcemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ergocalciferol
- Aluminum hydroxide + Ergocalciferol Moderate
- Calcium acetate + Ergocalciferol Moderate
- Calcium carbonate + Ergocalciferol Moderate
- Calcium chloride + Ergocalciferol Moderate
- Calcium citrate + Ergocalciferol Moderate
- Calcium gluconate + Ergocalciferol Moderate
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Chlorothiazide with Ergocalciferol?
MediHelp rates the interaction as moderate. Chlorothiazide and Ergocalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics reduce urinary calcium excretion, and vitamin D increases calcium absorption from the gut. Combined use can lead to hypercalcemia, especially with high vitamin D doses or underlying hyperparathyroidism or renal disease.
How serious is the interaction between Chlorothiazide and Ergocalciferol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium at baseline and periodically during therapy. Reduce the vitamin D dose or reconsider the thiazide if hypercalcemia occurs.
What other medicines interact with Ergocalciferol?
MediHelp also lists interactions of Ergocalciferol with, for example, Aluminum hydroxide, Calcium acetate, Calcium carbonate. The full list is on the Ergocalciferol page.
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