Interações medicamentosas
Chlorpromazine + Vorinostat
Gravidade: Grave
Chlorpromazine and Vorinostat: major interaction.
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Resumo
Vorinostat has been associated with QT prolongation, and chlorpromazine also prolongs the QT interval. Combined use may increase the risk of ventricular arrhythmia.
O que esta interação significa em palavras simples
Chlorpromazine and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Chlorpromazine belongs to Central Nervous System; Vorinostat belongs to Oncology.
Por que acontece
Additive QT interval prolongation; vorinostat's effect is not fully characterized.
O que fazer
Avoid if possible; if both are needed, monitor ECG and keep potassium and magnesium within normal range. Vorinostat can also cause electrolyte disturbances, so check these regularly.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chlorpromazine
- Chlorpromazine + Dofetilide Contraindicada
- Chlorpromazine + Dronedarone Contraindicada
- Chlorpromazine + Droperidol Contraindicada
- Chlorpromazine + Ibutilide Contraindicada
- Chlorpromazine + Metrizamide Contraindicada
- Chlorpromazine + Panobinostat Contraindicada
Outras interações de Vorinostat
- Thioridazine + Vorinostat Contraindicada
- Amiodarone + Vorinostat Grave
- Amisulpride + Vorinostat Grave
- Anagrelide + Vorinostat Grave
- Asenapine + Vorinostat Grave
- Clarithromycin + Vorinostat Grave
Perguntas frequentes
Can I take Chlorpromazine with Vorinostat?
MediHelp rates the interaction as major. Chlorpromazine and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vorinostat has been associated with QT prolongation, and chlorpromazine also prolongs the QT interval. Combined use may increase the risk of ventricular arrhythmia.
How serious is the interaction between Chlorpromazine and Vorinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if both are needed, monitor ECG and keep potassium and magnesium within normal range. Vorinostat can also cause electrolyte disturbances, so check these regularly.
What other medicines interact with Chlorpromazine?
MediHelp also lists interactions of Chlorpromazine with, for example, Dofetilide, Dronedarone, Droperidol. The full list is on the Chlorpromazine page.
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