Interações medicamentosas
Thioridazine + Vorinostat
Gravidade: Contraindicada
Thioridazine and Vorinostat: contraindicated interaction.
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Resumo
Vorinostat has been associated with QT prolongation, and thioridazine markedly prolongs QTc. The combination may increase the risk of torsades de pointes, particularly with electrolyte disturbances common in oncology patients.
O que esta interação significa em palavras simples
Thioridazine and Vorinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Thioridazine belongs to Central Nervous System; Vorinostat belongs to Oncology.
Por que acontece
Additive effects on cardiac repolarization leading to QT prolongation.
O que fazer
Avoid combining; use an alternative antipsychotic. If vorinostat is essential, correct potassium and magnesium and do not use thioridazine.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Thioridazine
- Abiraterone + Thioridazine Contraindicada
- Adagrasib + Thioridazine Contraindicada
- Amiodarone + Thioridazine Contraindicada
- Amisulpride + Thioridazine Contraindicada
- Amitriptyline + Thioridazine Contraindicada
- Amoxapine + Thioridazine Contraindicada
Outras interações de Vorinostat
Perguntas frequentes
Can I take Thioridazine with Vorinostat?
MediHelp rates the interaction as contraindicated. Thioridazine and Vorinostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vorinostat has been associated with QT prolongation, and thioridazine markedly prolongs QTc. The combination may increase the risk of torsades de pointes, particularly with electrolyte disturbances common in oncology patients.
How serious is the interaction between Thioridazine and Vorinostat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; use an alternative antipsychotic. If vorinostat is essential, correct potassium and magnesium and do not use thioridazine.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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