Interações medicamentosas
Amisulpride + Vorinostat
Gravidade: Grave
Amisulpride and Vorinostat: major interaction.
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Resumo
Both drugs can prolong the QT interval, so giving them together may add to the risk of serious ventricular arrhythmias, including torsades de pointes. The risk rises further with electrolyte disturbance, bradycardia or underlying cardiac disease.
O que esta interação significa em palavras simples
Amisulpride and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amisulpride belongs to Central Nervous System; Vorinostat belongs to Oncology.
Por que acontece
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
O que fazer
Avoid the combination where an alternative exists. If it cannot be avoided, obtain a baseline ECG, monitor ECGs during treatment and correct potassium and magnesium abnormalities.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amisulpride
- Amiodarone + Amisulpride Contraindicada
- Amisulpride + Arsenic trioxide Contraindicada
- Amisulpride + Disopyramide Contraindicada
- Amisulpride + Dofetilide Contraindicada
- Amisulpride + Droperidol Contraindicada
- Amisulpride + Ibutilide Contraindicada
Outras interações de Vorinostat
- Thioridazine + Vorinostat Contraindicada
- Amiodarone + Vorinostat Grave
- Anagrelide + Vorinostat Grave
- Asenapine + Vorinostat Grave
- Chlorpromazine + Vorinostat Grave
- Clarithromycin + Vorinostat Grave
Perguntas frequentes
Can I take Amisulpride with Vorinostat?
MediHelp rates the interaction as major. Amisulpride and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so giving them together may add to the risk of serious ventricular arrhythmias, including torsades de pointes. The risk rises further with electrolyte disturbance, bradycardia or underlying cardiac disease.
How serious is the interaction between Amisulpride and Vorinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where an alternative exists. If it cannot be avoided, obtain a baseline ECG, monitor ECGs during treatment and correct potassium and magnesium abnormalities.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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