Interações medicamentosas
Cholera vaccine + Cladribine
Gravidade: Grave
Cholera vaccine and Cladribine: major interaction.
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Resumo
Cladribine causes prolonged lymphocyte depletion, which can reduce the immune response to vaccines. The oral cholera vaccine is live attenuated, so there is also a theoretical risk of infection from the vaccine strain.
O que esta interação significa em palavras simples
Cholera vaccine and Cladribine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Cladribine-induced lymphopenia impairs vaccine immune responses and may permit replication of a live attenuated vaccine strain.
O que fazer
Avoid live vaccines during and after cladribine until lymphocyte counts have recovered. Where possible, complete vaccination at least 4 to 6 weeks before starting cladribine.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cladribine
- Adenovirus types 4 and 7 live + Cladribine Contraindicada
- Cladribine + Siponimod Contraindicada
- Cladribine + Tofacitinib Contraindicada
- Axicabtagene ciloleucel + Cladribine Grave
- Belatacept + Cladribine Grave
- Brexucabtagene autoleucel + Cladribine Grave
Perguntas frequentes
Can I take Cholera vaccine with Cladribine?
MediHelp rates the interaction as major. Cholera vaccine and Cladribine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cladribine causes prolonged lymphocyte depletion, which can reduce the immune response to vaccines. The oral cholera vaccine is live attenuated, so there is also a theoretical risk of infection from the vaccine strain.
How serious is the interaction between Cholera vaccine and Cladribine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during and after cladribine until lymphocyte counts have recovered. Where possible, complete vaccination at least 4 to 6 weeks before starting cladribine.
What other medicines interact with Cladribine?
MediHelp also lists interactions of Cladribine with, for example, Adenovirus types 4 and 7 live, Siponimod, Tofacitinib. The full list is on the Cladribine page.
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