Interações medicamentosas
Cladribine + Tofacitinib
Gravidade: Contraindicada
Cladribine and Tofacitinib: contraindicated interaction.
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Resumo
Cladribine causes prolonged lymphopenia, and tofacitinib adds immunosuppression, markedly increasing the risk of serious infection. Oral cladribine labeling advises against combination with immunosuppressive therapies.
O que esta interação significa em palavras simples
Cladribine and Tofacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cladribine belongs to Oncology; Tofacitinib belongs to Musculoskeletal.
Por que acontece
Additive lymphocyte depletion and immunosuppression.
O que fazer
Do not combine; avoid tofacitinib during and after cladribine courses while lymphopenia persists. Select alternative therapy and monitor lymphocyte counts.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Tofacitinib
- Baricitinib + Tofacitinib Contraindicada
- Tofacitinib + Upadacitinib Contraindicada
- Abatacept + Tofacitinib Grave
- Anti-thymocyte + Tofacitinib Grave
- Antithymocyte globulin equine + Tofacitinib Grave
- Antithymocyte globulin rabbit + Tofacitinib Grave
Outras interações de Cladribine
- Adenovirus types 4 and 7 live + Cladribine Contraindicada
- Cladribine + Siponimod Contraindicada
- Axicabtagene ciloleucel + Cladribine Grave
- Belatacept + Cladribine Grave
- Brexucabtagene autoleucel + Cladribine Grave
- Cholera vaccine + Cladribine Grave
Perguntas frequentes
Can I take Cladribine with Tofacitinib?
MediHelp rates the interaction as contraindicated. Cladribine and Tofacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cladribine causes prolonged lymphopenia, and tofacitinib adds immunosuppression, markedly increasing the risk of serious infection. Oral cladribine labeling advises against combination with immunosuppressive therapies.
How serious is the interaction between Cladribine and Tofacitinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; avoid tofacitinib during and after cladribine courses while lymphopenia persists. Select alternative therapy and monitor lymphocyte counts.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Upadacitinib, Abatacept. The full list is on the Tofacitinib page.
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