Interações medicamentosas
Cholestyramine + Vitamin k1
Gravidade: Moderada
Cholestyramine and Vitamin k1: moderate interaction.
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Resumo
Long-term cholestyramine can reduce vitamin K absorption and lead to hypoprothrombinemia and increased bleeding tendency. The risk is greater in patients on anticoagulants or with malnutrition or liver disease.
O que esta interação significa em palavras simples
Cholestyramine and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholestyramine belongs to Cardiovascular; Vitamin k1 belongs to Cardiovascular.
Por que acontece
Cholestyramine binds bile acids and impairs micelle formation, reducing absorption of fat-soluble vitamin K.
O que fazer
Monitor INR or prothrombin time during prolonged cholestyramine therapy and supplement vitamin K if prolonged. Give vitamin K separately from the resin.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cholestyramine
Outras interações de Vitamin k1
- Vitamin k1 + Warfarin Grave
- Colestipol + Vitamin k1 Moderada
- Ketorolac intranasal + Vitamin k1 Moderada
- Mineral oil + Vitamin k1 Moderada
- Orlistat + Vitamin k1 Moderada
- Aescin + Vitamin k1 Leve
Perguntas frequentes
Can I take Cholestyramine with Vitamin k1?
MediHelp rates the interaction as moderate. Cholestyramine and Vitamin k1 can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Long-term cholestyramine can reduce vitamin K absorption and lead to hypoprothrombinemia and increased bleeding tendency. The risk is greater in patients on anticoagulants or with malnutrition or liver disease.
How serious is the interaction between Cholestyramine and Vitamin k1?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR or prothrombin time during prolonged cholestyramine therapy and supplement vitamin K if prolonged. Give vitamin K separately from the resin.
What other medicines interact with Cholestyramine?
MediHelp also lists interactions of Cholestyramine with, for example, Cholic acid, Deferasirox, Leflunomide. The full list is on the Cholestyramine page.
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