Interações medicamentosas
Ciprofloxacin + Cobimetinib
Gravidade: Grave
Ciprofloxacin and Cobimetinib: major interaction.
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Resumo
Cobimetinib is a CYP3A substrate, and ciprofloxacin is a moderate CYP3A inhibitor according to cobimetinib labeling. Co-use may raise cobimetinib exposure and increase its adverse effects, such as hemorrhage, rhabdomyolysis, liver toxicity and retinopathy.
O que esta interação significa em palavras simples
Ciprofloxacin and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Cobimetinib belongs to Oncology.
Por que acontece
Ciprofloxacin inhibits CYP3A4, reducing cobimetinib metabolism and raising its exposure.
O que fazer
Prefer an alternative antibiotic. If a moderate CYP3A inhibitor is needed for 14 days or less, cobimetinib labeling recommends reducing the dose to 20 mg, and the usual dose is resumed after the inhibitor is stopped.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Ciprofloxacin
- Agomelatine + Ciprofloxacin Contraindicada
- Ciprofloxacin + Fezolinetant Contraindicada
- Ciprofloxacin + Thioridazine Contraindicada
- Ciprofloxacin + Tizanidine Contraindicada
- Ciprofloxacin + Vandetanib Contraindicada
- Alosetron + Ciprofloxacin Grave
Outras interações de Cobimetinib
- Cobimetinib + Efavirenz Contraindicada
- Cobimetinib + Posaconazole Contraindicada
- Amobarbital + Cobimetinib Grave
- Apalutamide + Cobimetinib Grave
- Aprepitant + Cobimetinib Grave
- Bosentan + Cobimetinib Grave
Perguntas frequentes
Can I take Ciprofloxacin with Cobimetinib?
MediHelp rates the interaction as major. Ciprofloxacin and Cobimetinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobimetinib is a CYP3A substrate, and ciprofloxacin is a moderate CYP3A inhibitor according to cobimetinib labeling. Co-use may raise cobimetinib exposure and increase its adverse effects, such as hemorrhage, rhabdomyolysis, liver toxicity and retinopathy.
How serious is the interaction between Ciprofloxacin and Cobimetinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative antibiotic. If a moderate CYP3A inhibitor is needed for 14 days or less, cobimetinib labeling recommends reducing the dose to 20 mg, and the usual dose is resumed after the inhibitor is stopped.
What other medicines interact with Ciprofloxacin?
MediHelp also lists interactions of Ciprofloxacin with, for example, Agomelatine, Fezolinetant, Thioridazine. The full list is on the Ciprofloxacin page.
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