Interações medicamentosas
Cisplatin + Topotecan
Gravidade: Grave
Cisplatin and Topotecan: major interaction.
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Resumo
Cisplatin and topotecan both suppress bone marrow, and together they produce more severe neutropenia and thrombocytopenia than either drug alone. Myelosuppression can be dose-limiting and may lead to infection or bleeding.
O que esta interação significa em palavras simples
Cisplatin and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Topotecan belongs to Oncology.
Por que acontece
Additive pharmacodynamic myelosuppression, with possible sequence-dependent enhancement of toxicity.
O que fazer
Monitor complete blood counts frequently and reduce topotecan dose or delay cycles for severe cytopenias. Follow established regimen sequencing and use growth factor support when indicated.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cisplatin
- Cidofovir + Cisplatin Contraindicada
- Adefovir + Cisplatin Grave
- Adenovirus types 4 and 7 live + Cisplatin Grave
- Amikacin + Cisplatin Grave
- Amphotericin b deoxycholate + Cisplatin Grave
- Amphotericin b + Cisplatin Grave
Outras interações de Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicada
- Amiodarone + Topotecan Grave
- Cobicistat + Topotecan Grave
- Cyclosporine + Topotecan Grave
- Cyclosporin + Topotecan Grave
- Darunavir + Topotecan Grave
Perguntas frequentes
Can I take Cisplatin with Topotecan?
MediHelp rates the interaction as major. Cisplatin and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cisplatin and topotecan both suppress bone marrow, and together they produce more severe neutropenia and thrombocytopenia than either drug alone. Myelosuppression can be dose-limiting and may lead to infection or bleeding.
How serious is the interaction between Cisplatin and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce topotecan dose or delay cycles for severe cytopenias. Follow established regimen sequencing and use growth factor support when indicated.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
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