Interações medicamentosas
Cyclosporin + Topotecan
Gravidade: Grave
Cyclosporin and Topotecan: major interaction.
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Resumo
Cyclosporine raises topotecan exposure, particularly with oral topotecan, which may intensify myelosuppression and gastrointestinal toxicity. Both transporters involved in topotecan efflux are inhibited by cyclosporine.
O que esta interação significa em palavras simples
Cyclosporin and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Topotecan belongs to Oncology.
Por que acontece
Cyclosporine inhibits P-glycoprotein and BCRP efflux of topotecan, increasing its absorption and reducing clearance.
O que fazer
Avoid concomitant use, especially with oral topotecan; if unavoidable, monitor blood counts frequently and consider dose reduction.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicada
- Aliskiren + Cyclosporin Contraindicada
- Bcg vaccine live + Cyclosporin Contraindicada
- Bosentan + Cyclosporin Contraindicada
- Cidofovir + Cyclosporin Contraindicada
- Cyclosporin + Dengue vaccine Contraindicada
Outras interações de Topotecan
- Adenovirus types 4 and 7 live + Topotecan Contraindicada
- Amiodarone + Topotecan Grave
- Cisplatin + Topotecan Grave
- Cobicistat + Topotecan Grave
- Cyclosporine + Topotecan Grave
- Darunavir + Topotecan Grave
Perguntas frequentes
Can I take Cyclosporin with Topotecan?
MediHelp rates the interaction as major. Cyclosporin and Topotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine raises topotecan exposure, particularly with oral topotecan, which may intensify myelosuppression and gastrointestinal toxicity. Both transporters involved in topotecan efflux are inhibited by cyclosporine.
How serious is the interaction between Cyclosporin and Topotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use, especially with oral topotecan; if unavoidable, monitor blood counts frequently and consider dose reduction.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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