Interações medicamentosas
Citalopram + Pimozide
Gravidade: Contraindicada
Citalopram and Pimozide: contraindicated interaction.
Última atualização Fontes: US FDA label
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Resumo
Both drugs prolong the QT interval, so combination raises the risk of torsades de pointes and sudden cardiac death. Pimozide labeling and citalopram labeling both caution against or contraindicate co-use with QT-prolonging drugs. Risk is greater at higher citalopram doses and in patients with electrolyte disturbance or cardiac disease.
O que esta interação significa em palavras simples
Citalopram and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Citalopram belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Por que acontece
Additive QT prolongation. Citalopram is also partly metabolized by CYP2D6 and CYP3A4, and pimozide is a CYP2D6 and CYP3A4 substrate, so pharmacokinetic effects may add to this.
O que fazer
Do not co-administer. Choose an antidepressant with less QT effect, such as sertraline, and review the antipsychotic need.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Referências
Outras interações de Pimozide
- Adagrasib + Pimozide Contraindicada
- Amiodarone + Pimozide Contraindicada
- Amisulpride + Pimozide Contraindicada
- Amitriptyline + Pimozide Contraindicada
- Amoxapine + Pimozide Contraindicada
- Anagrelide + Pimozide Contraindicada
Outras interações de Citalopram
- Cisapride + Citalopram Contraindicada
- Citalopram + Dronedarone Contraindicada
- Citalopram + Escitalopram Contraindicada
- Citalopram + Isocarboxazid Contraindicada
- Citalopram + Methylene blue Contraindicada
- Citalopram + Phenelzine Contraindicada
Perguntas frequentes
Can I take Citalopram with Pimozide?
MediHelp rates the interaction as contraindicated. Citalopram and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs prolong the QT interval, so combination raises the risk of torsades de pointes and sudden cardiac death. Pimozide labeling and citalopram labeling both caution against or contraindicate co-use with QT-prolonging drugs. Risk is greater at higher citalopram doses and in patients with electrolyte disturbance or cardiac disease.
How serious is the interaction between Citalopram and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Choose an antidepressant with less QT effect, such as sertraline, and review the antipsychotic need.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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