Interações medicamentosas
Citalopram + Phenelzine
Gravidade: Contraindicada
Citalopram and Phenelzine: contraindicated interaction.
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Resumo
Citalopram raises synaptic serotonin by blocking reuptake, and phenelzine (an irreversible non-selective MAO inhibitor) prevents its breakdown. Serotonin syndrome with agitation, hyperthermia, clonus and autonomic instability can develop, sometimes fatally.
O que esta interação significa em palavras simples
Citalopram and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Citalopram belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Por que acontece
Serotonin reuptake inhibition combined with MAO inhibition causes excess serotonergic activity
O que fazer
Contraindicated. Wait at least 14 days after stopping phenelzine before starting the other drug; allow at least 2 weeks between stopping an irreversible MAOI and starting citalopram, and about a week the other way round.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Citalopram
- Cisapride + Citalopram Contraindicada
- Citalopram + Dronedarone Contraindicada
- Citalopram + Escitalopram Contraindicada
- Citalopram + Isocarboxazid Contraindicada
- Citalopram + Methylene blue Contraindicada
- Citalopram + Pimozide Contraindicada
Outras interações de Phenelzine
- 5-HTP + Phenelzine Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amoxapine + Phenelzine Contraindicada
- Atomoxetine + Phenelzine Contraindicada
- Benzphetamine + Phenelzine Contraindicada
- Brimonidine + Phenelzine Contraindicada
Perguntas frequentes
Can I take Citalopram with Phenelzine?
MediHelp rates the interaction as contraindicated. Citalopram and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Citalopram raises synaptic serotonin by blocking reuptake, and phenelzine (an irreversible non-selective MAO inhibitor) prevents its breakdown. Serotonin syndrome with agitation, hyperthermia, clonus and autonomic instability can develop, sometimes fatally.
How serious is the interaction between Citalopram and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Contraindicated. Wait at least 14 days after stopping phenelzine before starting the other drug; allow at least 2 weeks between stopping an irreversible MAOI and starting citalopram, and about a week the other way round.
What other medicines interact with Citalopram?
MediHelp also lists interactions of Citalopram with, for example, Cisapride, Dronedarone, Escitalopram. The full list is on the Citalopram page.
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