Interações medicamentosas
Clarithromycin + Lonafarnib
Gravidade: Contraindicada
Clarithromycin and Lonafarnib: contraindicated interaction.
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Resumo
Lonafarnib is a sensitive CYP3A4 substrate and clarithromycin can greatly raise its levels, increasing the risk of toxicity including gastrointestinal effects, liver injury, and QT prolongation.
O que esta interação significa em palavras simples
Clarithromycin and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Clarithromycin belongs to Anti Bacterial; Lonafarnib belongs to Miscellaneous.
Por que acontece
Clarithromycin inhibits CYP3A4, decreasing lonafarnib clearance.
O que fazer
Do not coadminister; use an alternative antibiotic, with ECG and liver function monitoring if exposure occurs.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Clarithromycin
- Astemizole + Clarithromycin Contraindicada
- Avanafil + Clarithromycin Contraindicada
- Cisapride + Clarithromycin Contraindicada
- Clarithromycin + Colchicine Contraindicada
- Clarithromycin + Conivaptan Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
Outras interações de Lonafarnib
- Alfuzosin + Lonafarnib Contraindicada
- Amobarbital + Lonafarnib Contraindicada
- Apalutamide + Lonafarnib Contraindicada
- Bosentan + Lonafarnib Contraindicada
- Carbamazepine + Lonafarnib Contraindicada
- Crizotinib + Lonafarnib Contraindicada
Perguntas frequentes
Can I take Clarithromycin with Lonafarnib?
MediHelp rates the interaction as contraindicated. Clarithromycin and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate and clarithromycin can greatly raise its levels, increasing the risk of toxicity including gastrointestinal effects, liver injury, and QT prolongation.
How serious is the interaction between Clarithromycin and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; use an alternative antibiotic, with ECG and liver function monitoring if exposure occurs.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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