Interações medicamentosas
Crizotinib + Lonafarnib
Gravidade: Contraindicada
Crizotinib and Lonafarnib: contraindicated interaction.
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Resumo
Lonafarnib is a sensitive CYP3A4 substrate, and crizotinib is a moderate CYP3A4 inhibitor, so lonafarnib exposure may increase considerably. This raises the risk of toxicity such as gastrointestinal effects, hepatotoxicity and QT prolongation.
O que esta interação significa em palavras simples
Crizotinib and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Crizotinib belongs to Oncology; Lonafarnib belongs to Miscellaneous.
Por que acontece
Crizotinib inhibits CYP3A4-mediated metabolism of lonafarnib.
O que fazer
Avoid the combination in line with lonafarnib labeling for CYP3A inhibitors. If it cannot be avoided, a specialist should guide dose reduction and monitoring.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Crizotinib
- Crizotinib + Flibanserin Contraindicada
- Crizotinib + Lomitapide Contraindicada
- Crizotinib + Pimozide Contraindicada
- Crizotinib + Saquinavir Contraindicada
- Crizotinib + Thioridazine Contraindicada
- Adagrasib + Crizotinib Grave
Outras interações de Lonafarnib
- Alfuzosin + Lonafarnib Contraindicada
- Amobarbital + Lonafarnib Contraindicada
- Apalutamide + Lonafarnib Contraindicada
- Bosentan + Lonafarnib Contraindicada
- Carbamazepine + Lonafarnib Contraindicada
- Clarithromycin + Lonafarnib Contraindicada
Perguntas frequentes
Can I take Crizotinib with Lonafarnib?
MediHelp rates the interaction as contraindicated. Crizotinib and Lonafarnib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Lonafarnib is a sensitive CYP3A4 substrate, and crizotinib is a moderate CYP3A4 inhibitor, so lonafarnib exposure may increase considerably. This raises the risk of toxicity such as gastrointestinal effects, hepatotoxicity and QT prolongation.
How serious is the interaction between Crizotinib and Lonafarnib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in line with lonafarnib labeling for CYP3A inhibitors. If it cannot be avoided, a specialist should guide dose reduction and monitoring.
What other medicines interact with Crizotinib?
MediHelp also lists interactions of Crizotinib with, for example, Flibanserin, Lomitapide, Pimozide. The full list is on the Crizotinib page.
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