Interações medicamentosas
Clemastine + Dextromoramide
Gravidade: Grave
Clemastine and Dextromoramide: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Dextromoramide is a potent opioid, and a sedating antihistamine can substantially add to sedation and psychomotor impairment. Respiratory depression is a risk, especially at higher opioid doses.
O que esta interação significa em palavras simples
Clemastine and Dextromoramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS and respiratory depression from the opioid agonist and the sedating H1 antihistamine.
O que fazer
Use the lowest effective doses and monitor for sedation and respiratory depression. Prefer a non-sedating antihistamine and advise avoiding alcohol and driving.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Clemastine
Perguntas frequentes
Can I take Clemastine with Dextromoramide?
MediHelp rates the interaction as major. Clemastine and Dextromoramide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dextromoramide is a potent opioid, and a sedating antihistamine can substantially add to sedation and psychomotor impairment. Respiratory depression is a risk, especially at higher opioid doses.
How serious is the interaction between Clemastine and Dextromoramide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression. Prefer a non-sedating antihistamine and advise avoiding alcohol and driving.
What other medicines interact with Clemastine?
MediHelp also lists interactions of Clemastine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Buprenorphine buccal. The full list is on the Clemastine page.
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