Interações medicamentosas
Clomipramine + Methylene blue
Gravidade: Contraindicada
Clomipramine and Methylene blue: contraindicated interaction.
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Resumo
Methylene blue inhibits monoamine oxidase A, and combining it with a strongly serotonergic tricyclic can cause serotonin syndrome. Severe cases involve hyperthermia, rigidity, seizures and altered consciousness.
O que esta interação significa em palavras simples
Clomipramine and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
MAO-A inhibition by methylene blue combined with serotonin reuptake inhibition by clomipramine leads to excess serotonin.
O que fazer
Avoid unless methylene blue is needed for a life-threatening condition. If it is, stop clomipramine and monitor for serotonin toxicity; do not restart for at least 24 hours after the last methylene blue dose.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Clomipramine
- Arsenic trioxide + Clomipramine Contraindicada
- Clomipramine + Dofetilide Contraindicada
- Clomipramine + Droperidol Contraindicada
- Clomipramine + Isocarboxazid Contraindicada
- Clomipramine + Pentamidine Contraindicada
- Clomipramine + Phenelzine Contraindicada
Perguntas frequentes
Can I take Clomipramine with Methylene blue?
MediHelp rates the interaction as contraindicated. Clomipramine and Methylene blue are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylene blue inhibits monoamine oxidase A, and combining it with a strongly serotonergic tricyclic can cause serotonin syndrome. Severe cases involve hyperthermia, rigidity, seizures and altered consciousness.
How serious is the interaction between Clomipramine and Methylene blue?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless methylene blue is needed for a life-threatening condition. If it is, stop clomipramine and monitor for serotonin toxicity; do not restart for at least 24 hours after the last methylene blue dose.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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