Interações medicamentosas
Arsenic trioxide + Clomipramine
Gravidade: Contraindicada
Arsenic trioxide and Clomipramine: contraindicated interaction.
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Resumo
Arsenic trioxide causes marked QT prolongation and has been linked to torsades de pointes. Clomipramine also prolongs QT, so the combination adds serious arrhythmic risk.
O que esta interação significa em palavras simples
Arsenic trioxide and Clomipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Arsenic trioxide belongs to Oncology; Clomipramine belongs to Central Nervous System.
Por que acontece
Additive QT prolongation by effects on cardiac ion channels.
O que fazer
Avoid the combination and use an antidepressant with minimal QT effect. If it cannot be avoided, use close ECG and electrolyte monitoring.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Clomipramine
- Clomipramine + Dofetilide Contraindicada
- Clomipramine + Droperidol Contraindicada
- Clomipramine + Isocarboxazid Contraindicada
- Clomipramine + Methylene blue Contraindicada
- Clomipramine + Pentamidine Contraindicada
- Clomipramine + Phenelzine Contraindicada
Outras interações de Arsenic trioxide
- Amiodarone + Arsenic trioxide Contraindicada
- Amisulpride + Arsenic trioxide Contraindicada
- Arsenic trioxide + Dronedarone Contraindicada
- Arsenic trioxide + Fluphenazine Contraindicada
- Arsenic trioxide + Gemifloxacin Contraindicada
- Arsenic trioxide + Hydroxychloroquine Contraindicada
Perguntas frequentes
Can I take Arsenic trioxide with Clomipramine?
MediHelp rates the interaction as contraindicated. Arsenic trioxide and Clomipramine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Arsenic trioxide causes marked QT prolongation and has been linked to torsades de pointes. Clomipramine also prolongs QT, so the combination adds serious arrhythmic risk.
How serious is the interaction between Arsenic trioxide and Clomipramine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antidepressant with minimal QT effect. If it cannot be avoided, use close ECG and electrolyte monitoring.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Dofetilide, Droperidol, Isocarboxazid. The full list is on the Clomipramine page.
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