Interações medicamentosas
Clopidogrel + Omeprazole
Gravidade: Grave
Clopidogrel and Omeprazole: major interaction.
Última atualização Fontes: SPS (NHS), EMA SmPC, NCBI (US National Library of Medicine)
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Omeprazole inhibits CYP2C19, reducing clopidogrel’s bioactivation and antiplatelet effect, which may increase risk of thrombotic/cardiovascular events.
O que esta interação significa em palavras simples
Clopidogrel and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clopidogrel belongs to Cardiovascular; Omeprazole belongs to Gastrointestinal Tract.
Por que acontece
CYP2C19 inhibition by omeprazole decreases formation of clopidogrel’s active metabolite → reduced platelet inhibition.
O que fazer
Avoid coadministration. Use an alternative acid suppressant (e.g., pantoprazole) or consider a non–CYP2C19-dependent P2Y12 inhibitor when appropriate.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Omeprazole
- Mavacamten + Omeprazole Contraindicada
- Omeprazole + Rilpivirine Contraindicada
- Acalabrutinib + Omeprazole Grave
- Atazanavir + Omeprazole Grave
- Citalopram + Omeprazole Grave
- Dacomitinib + Omeprazole Grave
Outras interações de Clopidogrel
Perguntas frequentes
Can I take Clopidogrel with Omeprazole?
MediHelp rates the interaction as major. Clopidogrel and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Omeprazole inhibits CYP2C19, reducing clopidogrel’s bioactivation and antiplatelet effect, which may increase risk of thrombotic/cardiovascular events.
How serious is the interaction between Clopidogrel and Omeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. Use an alternative acid suppressant (e.g., pantoprazole) or consider a non–CYP2C19-dependent P2Y12 inhibitor when appropriate.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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