Interações medicamentosas
Dacomitinib + Omeprazole
Gravidade: Grave
Dacomitinib and Omeprazole: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Omeprazole lowers dacomitinib concentrations, which may reduce its antitumour efficacy. Dacomitinib absorption depends on gastric acidity.
O que esta interação significa em palavras simples
Dacomitinib and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacomitinib belongs to Oncology; Omeprazole belongs to Gastrointestinal Tract.
Por que acontece
Increased gastric pH reduces dacomitinib solubility and absorption.
O que fazer
Avoid PPIs with dacomitinib. If acid suppression is needed, use a locally acting antacid or an H2 antagonist, dosing dacomitinib at least 6 hours before or 10 hours after the H2 blocker.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Dacomitinib e Omeprazole, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Omeprazole
- Mavacamten + Omeprazole Contraindicada
- Omeprazole + Rilpivirine Contraindicada
- Acalabrutinib + Omeprazole Grave
- Atazanavir + Omeprazole Grave
- Citalopram + Omeprazole Grave
- Clopidogrel + Omeprazole Grave
Outras interações de Dacomitinib
- Dacomitinib + Thioridazine Contraindicada
- Amitriptyline + Dacomitinib Grave
- Atomoxetine + Dacomitinib Grave
- Brexpiprazole + Dacomitinib Grave
- Clomipramine + Dacomitinib Grave
- Dacomitinib + Desipramine Grave
Perguntas frequentes
Can I take Dacomitinib with Omeprazole?
MediHelp rates the interaction as major. Dacomitinib and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Omeprazole lowers dacomitinib concentrations, which may reduce its antitumour efficacy. Dacomitinib absorption depends on gastric acidity.
How serious is the interaction between Dacomitinib and Omeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with dacomitinib. If acid suppression is needed, use a locally acting antacid or an H2 antagonist, dosing dacomitinib at least 6 hours before or 10 hours after the H2 blocker.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
