Interações medicamentosas
Atazanavir + Omeprazole
Gravidade: Grave
Atazanavir and Omeprazole: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Atazanavir needs an acidic environment to dissolve, and omeprazole substantially lowers its plasma concentrations. This can cause loss of virologic control and resistance.
O que esta interação significa em palavras simples
Atazanavir and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Omeprazole belongs to Gastrointestinal Tract.
Por que acontece
Increased gastric pH reduces atazanavir solubility and absorption.
O que fazer
Avoid PPIs in treatment-experienced patients. In naive patients, use no more than omeprazole 20 mg daily, taken about 12 hours before ritonavir-boosted atazanavir.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Atazanavir e Omeprazole, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Omeprazole
- Mavacamten + Omeprazole Contraindicada
- Omeprazole + Rilpivirine Contraindicada
- Acalabrutinib + Omeprazole Grave
- Citalopram + Omeprazole Grave
- Clopidogrel + Omeprazole Grave
- Dacomitinib + Omeprazole Grave
Outras interações de Atazanavir
- Alfuzosin + Atazanavir Contraindicada
- Atazanavir + Avanafil Contraindicada
- Atazanavir + Dronedarone Contraindicada
- Atazanavir + Eletriptan Contraindicada
- Atazanavir + Eplerenone Contraindicada
- Atazanavir + Ergotamine Contraindicada
Perguntas frequentes
Can I take Atazanavir with Omeprazole?
MediHelp rates the interaction as major. Atazanavir and Omeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir needs an acidic environment to dissolve, and omeprazole substantially lowers its plasma concentrations. This can cause loss of virologic control and resistance.
How serious is the interaction between Atazanavir and Omeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs in treatment-experienced patients. In naive patients, use no more than omeprazole 20 mg daily, taken about 12 hours before ritonavir-boosted atazanavir.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
