Interações medicamentosas
Clotrimazole + Cyclosporine
Gravidade: Moderada
Clotrimazole and Cyclosporine: moderate interaction.
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Resumo
Systemic clotrimazole, such as lozenges or troches, may inhibit CYP3A4 and raise cyclosporine concentrations. Cyclosporine has a narrow therapeutic index, so raised levels may cause nephrotoxicity. Topical use is unlikely to matter.
O que esta interação significa em palavras simples
Clotrimazole and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Clotrimazole may inhibit CYP3A4 and P-glycoprotein, reducing cyclosporine clearance.
O que fazer
Monitor cyclosporine trough levels and renal function when oral clotrimazole is started or stopped, and adjust the cyclosporine dose accordingly. No action is needed for topical use.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Clotrimazole
- Clotrimazole + Lomitapide Grave
- Clotrimazole + Mavacamten Grave
- Clotrimazole + Mobocertinib Grave
- Clotrimazole + Voclosporin Grave
- Bosutinib + Clotrimazole Moderada
- Cannabidiol + Clotrimazole Moderada
Perguntas frequentes
Can I take Clotrimazole with Cyclosporine?
MediHelp rates the interaction as moderate. Clotrimazole and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic clotrimazole, such as lozenges or troches, may inhibit CYP3A4 and raise cyclosporine concentrations. Cyclosporine has a narrow therapeutic index, so raised levels may cause nephrotoxicity. Topical use is unlikely to matter.
How serious is the interaction between Clotrimazole and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function when oral clotrimazole is started or stopped, and adjust the cyclosporine dose accordingly. No action is needed for topical use.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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