Interações medicamentosas
Bosutinib + Clotrimazole
Gravidade: Moderada
Bosutinib and Clotrimazole: moderate interaction.
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Resumo
Systemic clotrimazole exposure is low with topical or local use, but oral lozenge use can inhibit CYP3A4 and potentially raise bosutinib levels. Higher bosutinib exposure could increase gastrointestinal, hepatic and myelosuppressive toxicity.
O que esta interação significa em palavras simples
Bosutinib and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bosutinib belongs to Oncology; Clotrimazole belongs to Anti Fungals.
Por que acontece
Clotrimazole is a CYP3A4 inhibitor that may reduce bosutinib metabolism.
O que fazer
Prefer topical or vaginal forms, or an alternative antifungal if systemic exposure is expected. Monitor for bosutinib toxicity and liver enzymes if combined.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Clotrimazole
- Clotrimazole + Lomitapide Grave
- Clotrimazole + Mavacamten Grave
- Clotrimazole + Mobocertinib Grave
- Clotrimazole + Voclosporin Grave
- Cannabidiol + Clotrimazole Moderada
- Clotrimazole + Cyclosporine Moderada
Outras interações de Bosutinib
- Amiodarone + Bosutinib Grave
- Apalutamide + Bosutinib Grave
- Aprepitant + Bosutinib Grave
- Bosentan + Bosutinib Grave
- Bosutinib + Carbamazepine Grave
- Bosutinib + Chlorpromazine Grave
Perguntas frequentes
Can I take Bosutinib with Clotrimazole?
MediHelp rates the interaction as moderate. Bosutinib and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic clotrimazole exposure is low with topical or local use, but oral lozenge use can inhibit CYP3A4 and potentially raise bosutinib levels. Higher bosutinib exposure could increase gastrointestinal, hepatic and myelosuppressive toxicity.
How serious is the interaction between Bosutinib and Clotrimazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer topical or vaginal forms, or an alternative antifungal if systemic exposure is expected. Monitor for bosutinib toxicity and liver enzymes if combined.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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