Interações medicamentosas
Cannabidiol + Clotrimazole
Gravidade: Moderada
Cannabidiol and Clotrimazole: moderate interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Systemic clotrimazole exposure (for example from lozenges or troches) may inhibit CYP3A4 and raise cannabidiol concentrations. This could increase sedation, somnolence and liver enzyme elevations. The effect is expected to be modest with topical use.
O que esta interação significa em palavras simples
Cannabidiol and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Clotrimazole belongs to Anti Fungals.
Por que acontece
Inhibition of CYP3A4-mediated metabolism of cannabidiol by clotrimazole.
O que fazer
Monitor for excess sedation and check liver enzymes if systemic clotrimazole is used. Consider reducing the cannabidiol dose if adverse effects appear.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Clotrimazole
- Clotrimazole + Lomitapide Grave
- Clotrimazole + Mavacamten Grave
- Clotrimazole + Mobocertinib Grave
- Clotrimazole + Voclosporin Grave
- Bosutinib + Clotrimazole Moderada
- Clotrimazole + Cyclosporine Moderada
Outras interações de Cannabidiol
- Cannabidiol + Phenytoin Grave
- Cannabidiol + Sodium valproate Grave
- Cannabidiol + Tacrolimus Grave
- Abiraterone + Cannabidiol Moderada
- Alogliptin-pioglitazone + Cannabidiol Moderada
- Amiodarone + Cannabidiol Moderada
Perguntas frequentes
Can I take Cannabidiol with Clotrimazole?
MediHelp rates the interaction as moderate. Cannabidiol and Clotrimazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic clotrimazole exposure (for example from lozenges or troches) may inhibit CYP3A4 and raise cannabidiol concentrations. This could increase sedation, somnolence and liver enzyme elevations. The effect is expected to be modest with topical use.
How serious is the interaction between Cannabidiol and Clotrimazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and check liver enzymes if systemic clotrimazole is used. Consider reducing the cannabidiol dose if adverse effects appear.
What other medicines interact with Clotrimazole?
MediHelp also lists interactions of Clotrimazole with, for example, Lomitapide, Mavacamten, Mobocertinib. The full list is on the Clotrimazole page.
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