Interações medicamentosas
Clozapine + Fesoterodine
Gravidade: Grave
Clozapine and Fesoterodine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Clozapine is strongly anticholinergic, and adding fesoterodine increases the risk of constipation, which with clozapine can progress to serious gastrointestinal hypomotility or ileus. Urinary retention, tachycardia and delirium may also occur.
O que esta interação significa em palavras simples
Clozapine and Fesoterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Fesoterodine belongs to Genitourinary.
Por que acontece
Additive antimuscarinic effects causing reduced gastrointestinal and bladder motility.
O que fazer
Avoid the combination if possible; if used, monitor bowel function closely, treat constipation proactively, and review for alternatives such as a non-antimuscarinic bladder agent.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Fesoterodine
Outras interações de Clozapine
- Clozapine + Deferiprone Contraindicada
- Clozapine + Irinotecan Contraindicada
- Clozapine + Pimozide Contraindicada
- Clozapine + Thioridazine Contraindicada
- Acalabrutinib + Clozapine Grave
- Adagrasib + Clozapine Grave
Perguntas frequentes
Can I take Clozapine with Fesoterodine?
MediHelp rates the interaction as major. Clozapine and Fesoterodine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clozapine is strongly anticholinergic, and adding fesoterodine increases the risk of constipation, which with clozapine can progress to serious gastrointestinal hypomotility or ileus. Urinary retention, tachycardia and delirium may also occur.
How serious is the interaction between Clozapine and Fesoterodine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if used, monitor bowel function closely, treat constipation proactively, and review for alternatives such as a non-antimuscarinic bladder agent.
What other medicines interact with Fesoterodine?
MediHelp also lists interactions of Fesoterodine with, for example, Bethanechol, Levoketoconazole, Pramlintide. The full list is on the Fesoterodine page.
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