Interações medicamentosas
Clozapine + Givinostat
Gravidade: Grave
Clozapine and Givinostat: major interaction.
Última atualização Fontes: UK SmPC
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Givinostat can prolong the QT interval, and clozapine adds further QT liability. Combined use may increase the risk of serious arrhythmia.
O que esta interação significa em palavras simples
Clozapine and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Givinostat belongs to Miscellaneous.
Por que acontece
Additive prolongation of cardiac repolarisation.
O que fazer
Avoid the combination if possible. If it is needed, obtain ECGs at initiation and during treatment, and hold givinostat if the QTc exceeds 500 ms or rises by more than 60 ms from baseline.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
- Clozapine Viatris 100 mg Orodispersible Tablets - SmPC sections 4.3/4.5 (class statement: medicines known to increase QTc interval; "caution should be exercised when clozapine is prescribed with medicines known to increase QTc interval, or causing electrolyte imbalance.") — electronic medicines compendium (UK SmPC)
Outras interações de Clozapine
- Clozapine + Deferiprone Contraindicada
- Clozapine + Irinotecan Contraindicada
- Clozapine + Pimozide Contraindicada
- Clozapine + Thioridazine Contraindicada
- Acalabrutinib + Clozapine Grave
- Adagrasib + Clozapine Grave
Outras interações de Givinostat
- Abiraterone + Givinostat Grave
- Amiodarone + Givinostat Grave
- Amisulpride + Givinostat Grave
- Amitriptyline + Givinostat Grave
- Anagrelide + Givinostat Grave
- Asenapine + Givinostat Grave
Perguntas frequentes
Can I take Clozapine with Givinostat?
MediHelp rates the interaction as major. Clozapine and Givinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Givinostat can prolong the QT interval, and clozapine adds further QT liability. Combined use may increase the risk of serious arrhythmia.
How serious is the interaction between Clozapine and Givinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If it is needed, obtain ECGs at initiation and during treatment, and hold givinostat if the QTc exceeds 500 ms or rises by more than 60 ms from baseline.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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