Interações medicamentosas
Clozapine + Methimazole
Gravidade: Grave
Clozapine and Methimazole: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Both drugs can cause agranulocytosis, and using them together may increase the risk of serious neutropenia and infection.
O que esta interação significa em palavras simples
Clozapine and Methimazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Methimazole belongs to Endocrine.
Por que acontece
Additive risk of bone marrow suppression and immune-mediated agranulocytosis.
O que fazer
Avoid the combination where possible, for example by using radioiodine or another treatment for hyperthyroidism. If used, monitor the absolute neutrophil count closely and stop for neutropenia.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Clozapine e Methimazole, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Outras interações de Clozapine
- Clozapine + Deferiprone Contraindicada
- Clozapine + Irinotecan Contraindicada
- Clozapine + Pimozide Contraindicada
- Clozapine + Thioridazine Contraindicada
- Acalabrutinib + Clozapine Grave
- Adagrasib + Clozapine Grave
Outras interações de Methimazole
- Carbamazepine + Methimazole Grave
- Methimazole + Propylthiouracil Grave
- Methimazole + Sodium iodide i-131 Grave
- Iodinated glycerol + Methimazole Moderada
- Iodine + Methimazole Moderada
- Lycopus + Methimazole Moderada
Perguntas frequentes
Can I take Clozapine with Methimazole?
MediHelp rates the interaction as major. Clozapine and Methimazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause agranulocytosis, and using them together may increase the risk of serious neutropenia and infection.
How serious is the interaction between Clozapine and Methimazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, for example by using radioiodine or another treatment for hyperthyroidism. If used, monitor the absolute neutrophil count closely and stop for neutropenia.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
