Interações medicamentosas
Cobicistat + Colchicine
Gravidade: Contraindicada
Cobicistat and Colchicine: contraindicated interaction.
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Resumo
Cobicistat strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing colchicine exposure. This can lead to life-threatening colchicine toxicity, and the combination is contraindicated in patients with renal or hepatic impairment.
O que esta interação significa em palavras simples
Cobicistat and Colchicine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Colchicine belongs to Genitourinary.
Por que acontece
Inhibition of CYP3A4 and P-glycoprotein reduces colchicine metabolism and efflux.
O que fazer
Do not use together in patients with renal or hepatic impairment. In others, reduce the colchicine dose substantially as per labeling and monitor for toxicity.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Colchicine
- Clarithromycin + Colchicine Contraindicada
- Colchicine + Cyclosporine Contraindicada
- Colchicine + Ensitrelvir Contraindicada
- Colchicine + Levoketoconazole Contraindicada
- Colchicine + Nirmatrelvir Contraindicada
- Colchicine + Nirmatrelvir / ritonavir Contraindicada
Outras interações de Cobicistat
- Alfuzosin + Cobicistat Contraindicada
- Apalutamide + Cobicistat Contraindicada
- Cobicistat + Dronedarone Contraindicada
- Cobicistat + Eletriptan Contraindicada
- Cobicistat + Eplerenone Contraindicada
- Cobicistat + Ergotamine Contraindicada
Perguntas frequentes
Can I take Cobicistat with Colchicine?
MediHelp rates the interaction as contraindicated. Cobicistat and Colchicine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat strongly inhibits CYP3A4 and P-glycoprotein, markedly increasing colchicine exposure. This can lead to life-threatening colchicine toxicity, and the combination is contraindicated in patients with renal or hepatic impairment.
How serious is the interaction between Cobicistat and Colchicine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together in patients with renal or hepatic impairment. In others, reduce the colchicine dose substantially as per labeling and monitor for toxicity.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cyclosporine, Ensitrelvir. The full list is on the Colchicine page.
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