Interações medicamentosas
Cobicistat + Ergotamine
Gravidade: Contraindicada
Cobicistat and Ergotamine: contraindicated interaction.
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Resumo
Cobicistat strongly inhibits CYP3A4 and can sharply raise ergotamine concentrations. This can precipitate acute ergotism with severe peripheral vasospasm and ischemia of the limbs, brain or heart.
O que esta interação significa em palavras simples
Cobicistat and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Ergotamine belongs to Central Nervous System.
Por que acontece
Inhibition of CYP3A4-mediated ergotamine metabolism.
O que fazer
Do not co-administer. Use a non-ergot migraine therapy during treatment with cobicistat.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Ergotamine
- Almotriptan + Ergotamine Contraindicada
- Atazanavir + Ergotamine Contraindicada
- Clarithromycin + Ergotamine Contraindicada
- Darunavir + Ergotamine Contraindicada
- Dihydroergotamine intranasal + Ergotamine Contraindicada
- Dihydroergotamine + Ergotamine Contraindicada
Outras interações de Cobicistat
- Alfuzosin + Cobicistat Contraindicada
- Apalutamide + Cobicistat Contraindicada
- Cobicistat + Colchicine Contraindicada
- Cobicistat + Dronedarone Contraindicada
- Cobicistat + Eletriptan Contraindicada
- Cobicistat + Eplerenone Contraindicada
Perguntas frequentes
Can I take Cobicistat with Ergotamine?
MediHelp rates the interaction as contraindicated. Cobicistat and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat strongly inhibits CYP3A4 and can sharply raise ergotamine concentrations. This can precipitate acute ergotism with severe peripheral vasospasm and ischemia of the limbs, brain or heart.
How serious is the interaction between Cobicistat and Ergotamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Use a non-ergot migraine therapy during treatment with cobicistat.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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