Interações medicamentosas
Cobicistat + Midazolam
Gravidade: Contraindicada
Cobicistat and Midazolam: contraindicated interaction.
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Resumo
Cobicistat strongly inhibits CYP3A and can greatly increase midazolam exposure, particularly after oral dosing. Prolonged sedation and respiratory depression can occur and are potentially life-threatening.
O que esta interação significa em palavras simples
Cobicistat and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cobicistat belongs to Miscellaneous; Midazolam belongs to Central Nervous System.
Por que acontece
Cobicistat inhibits intestinal and hepatic CYP3A4, blocking midazolam first-pass and systemic metabolism.
O que fazer
Avoid oral midazolam. If single-dose parenteral midazolam is needed, use a reduced dose in a monitored setting with respiratory support available.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Midazolam
- Atazanavir + Midazolam Contraindicada
- Darunavir + Midazolam Contraindicada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicada
- Fosamprenavir + Midazolam Contraindicada
- Indinavir + Midazolam Contraindicada
- Itraconazole + Midazolam Contraindicada
Outras interações de Cobicistat
- Alfuzosin + Cobicistat Contraindicada
- Apalutamide + Cobicistat Contraindicada
- Cobicistat + Colchicine Contraindicada
- Cobicistat + Dronedarone Contraindicada
- Cobicistat + Eletriptan Contraindicada
- Cobicistat + Eplerenone Contraindicada
Perguntas frequentes
Can I take Cobicistat with Midazolam?
MediHelp rates the interaction as contraindicated. Cobicistat and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat strongly inhibits CYP3A and can greatly increase midazolam exposure, particularly after oral dosing. Prolonged sedation and respiratory depression can occur and are potentially life-threatening.
How serious is the interaction between Cobicistat and Midazolam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral midazolam. If single-dose parenteral midazolam is needed, use a reduced dose in a monitored setting with respiratory support available.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Midazolam page.
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