Interações medicamentosas
Itraconazole + Midazolam
Gravidade: Contraindicada
Itraconazole and Midazolam: contraindicated interaction.
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Resumo
Itraconazole is a strong CYP3A4 inhibitor and raises midazolam exposure many-fold, especially with the oral route. Prolonged sedation and respiratory depression can occur.
O que esta interação significa em palavras simples
Itraconazole and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Itraconazole belongs to Anti Fungals; Midazolam belongs to Central Nervous System.
Por que acontece
Strong CYP3A4 inhibition markedly raises midazolam exposure
O que fazer
Oral midazolam is contraindicated; if IV midazolam is unavoidable, use a reduced dose with continuous monitoring.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Itraconazole
- Alfuzosin + Itraconazole Contraindicada
- Alprazolam + Itraconazole Contraindicada
- Avanafil + Itraconazole Contraindicada
- Conivaptan + Itraconazole Contraindicada
- Dihydroergotamine intranasal + Itraconazole Contraindicada
- Dihydroergotamine + Itraconazole Contraindicada
Outras interações de Midazolam
- Atazanavir + Midazolam Contraindicada
- Cobicistat + Midazolam Contraindicada
- Darunavir + Midazolam Contraindicada
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicada
- Fosamprenavir + Midazolam Contraindicada
- Indinavir + Midazolam Contraindicada
Perguntas frequentes
Can I take Itraconazole with Midazolam?
MediHelp rates the interaction as contraindicated. Itraconazole and Midazolam are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Itraconazole is a strong CYP3A4 inhibitor and raises midazolam exposure many-fold, especially with the oral route. Prolonged sedation and respiratory depression can occur.
How serious is the interaction between Itraconazole and Midazolam?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Oral midazolam is contraindicated; if IV midazolam is unavoidable, use a reduced dose with continuous monitoring.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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