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Interações medicamentosas

Colchicine + Teduglutide

Gravidade: Moderada

Colchicine and Teduglutide: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Teduglutide increases intestinal fluid absorption and may enhance absorption of oral drugs. For colchicine, a narrow therapeutic index drug, higher exposure is possible and could increase toxicity.

O que esta interação significa em palavras simples

Colchicine and Teduglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Colchicine belongs to Genitourinary; Teduglutide belongs to Endocrine.

Nível de evidência: Low

Por que acontece

Teduglutide improves intestinal absorptive function and fluid uptake, which may increase absorption of oral colchicine.

O que fazer

Monitor for signs of colchicine toxicity (diarrhea, nausea, muscle weakness) when starting teduglutide and adjust the colchicine dose if needed.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Colchicine with Teduglutide?

MediHelp rates the interaction as moderate. Colchicine and Teduglutide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teduglutide increases intestinal fluid absorption and may enhance absorption of oral drugs. For colchicine, a narrow therapeutic index drug, higher exposure is possible and could increase toxicity.

How serious is the interaction between Colchicine and Teduglutide?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of colchicine toxicity (diarrhea, nausea, muscle weakness) when starting teduglutide and adjust the colchicine dose if needed.

What other medicines interact with Colchicine?

MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.

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