Interações medicamentosas
Cyclosporin + Daunorubicin
Gravidade: Grave
Cyclosporin and Daunorubicin: major interaction.
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Resumo
Cyclosporine can increase daunorubicin exposure and prolong its effects, increasing myelosuppression, mucositis and cardiotoxicity. It has been used deliberately to overcome drug resistance, which requires dose consideration.
O que esta interação significa em palavras simples
Cyclosporin and Daunorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Daunorubicin belongs to Oncology.
Por que acontece
Cyclosporine inhibits P-glycoprotein efflux, reducing daunorubicin clearance.
O que fazer
Monitor blood counts and cardiac function closely and consider reducing the daunorubicin dose.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicada
- Aliskiren + Cyclosporin Contraindicada
- Bcg vaccine live + Cyclosporin Contraindicada
- Bosentan + Cyclosporin Contraindicada
- Cidofovir + Cyclosporin Contraindicada
- Cyclosporin + Dengue vaccine Contraindicada
Outras interações de Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicada
- Belatacept + Daunorubicin Grave
- Cyclosporine + Daunorubicin Grave
- Daunorubicin + Dengue vaccine Grave
- Daunorubicin + Etrasimod Grave
- Daunorubicin + Fingolimod Grave
Perguntas frequentes
Can I take Cyclosporin with Daunorubicin?
MediHelp rates the interaction as major. Cyclosporin and Daunorubicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine can increase daunorubicin exposure and prolong its effects, increasing myelosuppression, mucositis and cardiotoxicity. It has been used deliberately to overcome drug resistance, which requires dose consideration.
How serious is the interaction between Cyclosporin and Daunorubicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function closely and consider reducing the daunorubicin dose.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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