Interações medicamentosas
Cyclosporin + Tacrolimus
Gravidade: Contraindicada
Cyclosporin and Tacrolimus: contraindicated interaction.
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Resumo
Both are calcineurin inhibitors and together they increase nephrotoxicity, neurotoxicity and over-immunosuppression. Cyclosporine can also raise tacrolimus levels, and the two should not be given together.
O que esta interação significa em palavras simples
Cyclosporin and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclosporin belongs to Miscellaneous; Tacrolimus belongs to Miscellaneous.
Por que acontece
Additive calcineurin inhibition and toxicity, with competition for CYP3A4 and P-glycoprotein altering exposure of either drug.
O que fazer
Do not combine the two. When switching, stop one and wait at least 24 hours before starting the other, guided by drug levels and renal function.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicada
- Aliskiren + Cyclosporin Contraindicada
- Bcg vaccine live + Cyclosporin Contraindicada
- Bosentan + Cyclosporin Contraindicada
- Cidofovir + Cyclosporin Contraindicada
- Cyclosporin + Dengue vaccine Contraindicada
Outras interações de Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicada
- Bcg vaccine live + Tacrolimus Contraindicada
- Cidofovir + Tacrolimus Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicada
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicada
- Measles mumps and rubella vaccine + Tacrolimus Contraindicada
Perguntas frequentes
Can I take Cyclosporin with Tacrolimus?
MediHelp rates the interaction as contraindicated. Cyclosporin and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are calcineurin inhibitors and together they increase nephrotoxicity, neurotoxicity and over-immunosuppression. Cyclosporine can also raise tacrolimus levels, and the two should not be given together.
How serious is the interaction between Cyclosporin and Tacrolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine the two. When switching, stop one and wait at least 24 hours before starting the other, guided by drug levels and renal function.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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