Interações medicamentosas
Measles mumps and rubella vaccine live + Tacrolimus
Gravidade: Contraindicada
Measles mumps and rubella vaccine live and Tacrolimus: contraindicated interaction.
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Resumo
The MMR vaccine contains live attenuated viruses. In tacrolimus-treated patients these viruses may replicate unchecked and cause vaccine-strain disease, and the immune response is likely to be poor.
O que esta interação significa em palavras simples
Measles mumps and rubella vaccine live and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Calcineurin inhibition suppresses cellular immunity, permitting replication of live attenuated vaccine viruses.
O que fazer
Do not give MMR vaccine to patients on tacrolimus. Vaccinate before transplant or immunosuppression where possible, and check immunity by serology.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicada
- Bcg vaccine live + Tacrolimus Contraindicada
- Cidofovir + Tacrolimus Contraindicada
- Cyclosporin + Tacrolimus Contraindicada
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicada
- Measles mumps and rubella vaccine + Tacrolimus Contraindicada
Perguntas frequentes
Can I take Measles mumps and rubella vaccine live with Tacrolimus?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine live and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The MMR vaccine contains live attenuated viruses. In tacrolimus-treated patients these viruses may replicate unchecked and cause vaccine-strain disease, and the immune response is likely to be poor.
How serious is the interaction between Measles mumps and rubella vaccine live and Tacrolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give MMR vaccine to patients on tacrolimus. Vaccinate before transplant or immunosuppression where possible, and check immunity by serology.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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