Interações medicamentosas
Dabrafenib + Desogestrel-ethinyl estradiol
Gravidade: Grave
Dabrafenib and Desogestrel-ethinyl estradiol: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Dabrafenib is an inducer of CYP3A4 and can lower exposure to hormonal contraceptives. Contraceptive efficacy may be reduced, leading to a risk of pregnancy during treatment with a teratogenic agent.
O que esta interação significa em palavras simples
Dabrafenib and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Desogestrel-ethinyl estradiol belongs to Endocrine.
Por que acontece
Dabrafenib induces CYP3A4, accelerating metabolism of ethinyl estradiol and etonogestrel.
O que fazer
Use an effective non-hormonal contraceptive method during dabrafenib therapy and for a period after discontinuation, as specified in labeling.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Desogestrel-ethinyl estradiol
- Desogestrel-ethinyl estradiol + Fezolinetant Contraindicada
- Aminocaproic acid + Desogestrel-ethinyl estradiol Grave
- Amobarbital + Desogestrel-ethinyl estradiol Grave
- Anastrozole + Desogestrel-ethinyl estradiol Grave
- Apalutamide + Desogestrel-ethinyl estradiol Grave
- Atazanavir + Desogestrel-ethinyl estradiol Grave
Outras interações de Dabrafenib
Perguntas frequentes
Can I take Dabrafenib with Desogestrel-ethinyl estradiol?
MediHelp rates the interaction as major. Dabrafenib and Desogestrel-ethinyl estradiol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib is an inducer of CYP3A4 and can lower exposure to hormonal contraceptives. Contraceptive efficacy may be reduced, leading to a risk of pregnancy during treatment with a teratogenic agent.
How serious is the interaction between Dabrafenib and Desogestrel-ethinyl estradiol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an effective non-hormonal contraceptive method during dabrafenib therapy and for a period after discontinuation, as specified in labeling.
What other medicines interact with Desogestrel-ethinyl estradiol?
MediHelp also lists interactions of Desogestrel-ethinyl estradiol with, for example, Fezolinetant, Aminocaproic acid, Amobarbital. The full list is on the Desogestrel-ethinyl estradiol page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
