Interações medicamentosas
Dabrafenib + Deflazacort
Gravidade: Grave
Dabrafenib and Deflazacort: major interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Dabrafenib induces CYP3A4 and can substantially reduce exposure to deflazacort's active metabolite. This may lead to loss of corticosteroid effect.
O que esta interação significa em palavras simples
Dabrafenib and Deflazacort can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabrafenib belongs to Oncology; Deflazacort belongs to Miscellaneous.
Por que acontece
Dabrafenib induces CYP3A4, accelerating clearance of deflazacort's active metabolite.
O que fazer
Avoid the combination where possible, as deflazacort labeling advises against moderate or strong CYP3A4 inducers. If unavoidable, monitor for reduced efficacy and consider an alternative corticosteroid regimen.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicada
- Bcg vaccine live + Deflazacort Contraindicada
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicada
- Deflazacort + Measles mumps and rubella vaccine Contraindicada
- Deflazacort + Measles mumps and rubella vaccine live Contraindicada
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicada
Outras interações de Dabrafenib
Perguntas frequentes
Can I take Dabrafenib with Deflazacort?
MediHelp rates the interaction as major. Dabrafenib and Deflazacort can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib induces CYP3A4 and can substantially reduce exposure to deflazacort's active metabolite. This may lead to loss of corticosteroid effect.
How serious is the interaction between Dabrafenib and Deflazacort?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, as deflazacort labeling advises against moderate or strong CYP3A4 inducers. If unavoidable, monitor for reduced efficacy and consider an alternative corticosteroid regimen.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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