Interações medicamentosas
Cariprazine + Dabrafenib
Gravidade: Grave
Cariprazine and Dabrafenib: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Dabrafenib is a CYP3A4 inducer that may lower concentrations of cariprazine and its active metabolites, which are cleared by CYP3A4. The size of the effect is not well characterised, and loss of antipsychotic efficacy is possible.
O que esta interação significa em palavras simples
Cariprazine and Dabrafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cariprazine belongs to Central Nervous System; Dabrafenib belongs to Oncology.
Por que acontece
Dabrafenib induces CYP3A4, which may increase clearance of cariprazine and its active metabolites.
O que fazer
Avoid the combination where possible, as labeling advises against strong CYP3A4 inducers. If it is unavoidable, monitor for loss of psychiatric control and consider dose adjustment.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cariprazine
Outras interações de Dabrafenib
Perguntas frequentes
Can I take Cariprazine with Dabrafenib?
MediHelp rates the interaction as major. Cariprazine and Dabrafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dabrafenib is a CYP3A4 inducer that may lower concentrations of cariprazine and its active metabolites, which are cleared by CYP3A4. The size of the effect is not well characterised, and loss of antipsychotic efficacy is possible.
How serious is the interaction between Cariprazine and Dabrafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, as labeling advises against strong CYP3A4 inducers. If it is unavoidable, monitor for loss of psychiatric control and consider dose adjustment.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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