Drug interactions
Dacomitinib + Desipramine
Severity: Major
Dacomitinib and Desipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib is a strong CYP2D6 inhibitor, and desipramine is cleared mainly via CYP2D6. Desipramine exposure can rise markedly, increasing the risk of anticholinergic effects, cardiac conduction abnormalities and arrhythmia.
What this interaction means in plain words
Dacomitinib and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dacomitinib belongs to Oncology; Desipramine belongs to Central Nervous System.
Why it happens
Dacomitinib inhibits CYP2D6, reducing the metabolism of desipramine.
What to do
Avoid the combination if possible. If used, reduce the desipramine dose guided by plasma levels and ECG monitoring, and watch for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Dexlansoprazole Major
Frequently asked questions
Can I take Dacomitinib with Desipramine?
MediHelp rates the interaction as major. Dacomitinib and Desipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dacomitinib is a strong CYP2D6 inhibitor, and desipramine is cleared mainly via CYP2D6. Desipramine exposure can rise markedly, increasing the risk of anticholinergic effects, cardiac conduction abnormalities and arrhythmia.
How serious is the interaction between Dacomitinib and Desipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, reduce the desipramine dose guided by plasma levels and ECG monitoring, and watch for toxicity.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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