Interações medicamentosas
Dantrolene + Valoctocogene roxaparvovec
Gravidade: Grave
Dantrolene and Valoctocogene roxaparvovec: major interaction.
Última atualização Fontes: UK SmPC
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Valoctocogene roxaparvovec is a liver-directed gene therapy that commonly raises liver enzymes. Dantrolene, particularly with long-term use, can cause serious hepatotoxicity, so combined use may add to liver injury or confound its assessment.
O que esta interação significa em palavras simples
Dantrolene and Valoctocogene roxaparvovec can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dantrolene belongs to Musculoskeletal; Valoctocogene roxaparvovec belongs to Miscellaneous.
Por que acontece
Additive hepatotoxicity from a hepatotoxic drug and a liver-targeted gene therapy.
O que fazer
Monitor liver enzymes closely and consider alternative antispasticity therapy if dantrolene is not essential. Stop dantrolene if transaminases rise significantly.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Dantrolene
Outras interações de Valoctocogene roxaparvovec
Perguntas frequentes
Can I take Dantrolene with Valoctocogene roxaparvovec?
MediHelp rates the interaction as major. Dantrolene and Valoctocogene roxaparvovec can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Valoctocogene roxaparvovec is a liver-directed gene therapy that commonly raises liver enzymes. Dantrolene, particularly with long-term use, can cause serious hepatotoxicity, so combined use may add to liver injury or confound its assessment.
How serious is the interaction between Dantrolene and Valoctocogene roxaparvovec?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely and consider alternative antispasticity therapy if dantrolene is not essential. Stop dantrolene if transaminases rise significantly.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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